ABSTRACT
Gouty arthritis is caused due to the accumulation of uric acid crystals in joints which is the by-product of purinemetabolism in our body. The elevated level of uric acid in the blood is known as hyperuricemia that may resultsin deposition and inflammation of joints. This research experiment has examined the protective effect of Bacopamonnieri, an herb against the monosodium urate crystal-induced gouty arthritis in female Wistar albino rats. The ratswere divided into four groups with six rats in each group. Group-I was normal control rats, group-II rats were inducedwith monosodium urate crystal, group-III was administrated with B. monnieri in monosodium urate crystal-inducedrats, and group-IV was administrated with indomethacin in monosodium urate crystal-induced rats. The rats wereexamined for liver enzyme markers, antioxidant assays, and paw histopathology. The results of B. monnieri werecompared with that of standard drug indomethacin. The symptoms of arthritis, such as the elevation of paw volume,increased liver enzyme markers, decreased antioxidant enzymes, and histopathological changes, were found to bereversed to the normal level by the treatment with B. monnieri which is due to its anti-inflammatory properties. Asconclusion, B. monnieri has shown its anti-arthritic properties against gouty arthritis.
ABSTRACT
<p><b>OBJECTIVE</b>The purpose of the present study was to evaluate the nephroprotective and antioxidant properties of Triphala against bromobenzene-induced nephrotoxicity in female Wistar albino rats.</p><p><b>METHODS</b>Animals were divided into five groups of six rats and treated as follows: Group I was a normal control and received no treatment, Group II received only bromobenzene (10 mmol/kg), Groups III and IV received bromobenzene and Triphala (250 and 500 mg/kg, respectively), Group V received Triphala alone (500 mg/kg), and Group VI received bromobenzene and silymarin (100 mg/kg). Antioxidant status and serum kidney functional markers were analyzed.</p><p><b>RESULTS</b>Bromobenzene treatment resulted in significant (P< 0.05) decreases in the activities of antioxidant enzymes such as catalase, superoxide dismutase, glutathione-S-transferase and glutathione peroxidase as well as total reduced glutathione. There was a significant (P< 0.05) increase in lipid peroxidation in kidney tissue homogenates. There were significant (P< 0.05) reductions in the levels of serum total protein and albumin as well as significant (P< 0.05) increases in serum creatinine, urea and uric acid. The oral administration of two different doses (250 and 500 mg/kg) of Triphala in bromobenzene-treated rats normalized the tested parameters. The histopathological examinations of kidney sections of the experimental rats support the biochemical observations.</p><p><b>CONCLUSION</b>Triphala treatment alleviated the nephrotoxic effects of bromobenzene by increasing the activities of antioxidant enzymes and reducing the levels of lipid peroxidation and kidney functional markers.</p>
Subject(s)
Animals , Female , Rats , Acute Kidney Injury , Diagnosis , Metabolism , Antioxidants , Pharmacology , Bromobenzenes , Pharmacology , Disease Models, Animal , Kidney , Metabolism , Pathology , Kidney Function Tests , Medicine, Ayurvedic , Phyllanthus emblica , Plant Preparations , Chemistry , Pharmacology , Plant Structures , Protective Agents , Pharmacology , Rats, Wistar , Silymarin , Pharmacology , Terminalia , Treatment OutcomeABSTRACT
The present study was designed to investigate the antiperoxidative potential of p-coumaric acid, a common dietary phenol, in adjuvant-induced arthritis in rats.
ABSTRACT
To investigate the hepatoprotective efficacy of 6-gingerol against acetaminophen-induced hepatotoxicity in mice.